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Effect of the addition of rituximab to salvage chemotherapy prior to autologous stem cell transplant in aggressive CD20+ lymphoma: a cohort comparison from the NCIC Clinical Trials Group Study LY.12.
- Source :
-
Leukemia & Lymphoma . Jan2017, Vol. 58 Issue 1, p64-69. 6p. - Publication Year :
- 2017
-
Abstract
- The impact of the addition of rituximab to salvage chemotherapy prior to autologous stem cell transplant (ASCT) was evaluated in a retrospective subgroup analysis of NCIC CTG LY.12. Among 414 patients who relapsed following R-CHOP, 96 received salvage chemotherapy alone [R − cohort]; and 318 received rituximab with chemotherapy [R + cohort] following a protocol amendment. The R−cohort had a higher proportion of patients with PS ≥2 and relapse <1 year after R-CHOP. The response rate (45.6% vs. 25.0%,p = 0.0003), CR/CRu (15.7% vs. 4.2%,p = 0.003) and transplantation rate (51.9% vs. 31.3%,p = 0.0004) was higher in the R + cohort. Event-free (27% vs. 22%,p = 0.0954) and overall survival at four years (43% vs. 31%;p = 0.045) were greater in the R + cohort when the patients with best response SD/PD to R-CHOP were excluded. Addition of rituximab to salvage therapy before ASCT appears to improve the response rate, transplantation rate, and overall survival in patients with CD20+ lymphoma who responded to R-CHOP. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 10428194
- Volume :
- 58
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Leukemia & Lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 119355498
- Full Text :
- https://doi.org/10.1080/10428194.2016.1187274