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Causes of Death According to Death Certificates in Individuals with Dementia: A Cohort from the Swedish Dementia Registry.
- Source :
-
Journal of the American Geriatrics Society . Nov2016, Vol. 64 Issue 11, pe137-e142. 6p. 3 Charts. - Publication Year :
- 2016
-
Abstract
- Objectives The causes of death in dementia are not established, particularly in rarer dementias. The aim of this study is to calculate risk of death from specific causes for a broader spectrum of dementia diagnoses. Design Cohort study. Setting Swedish Dementia Registry (SveDem), 2007-2012. Participants Individuals with incident dementia registered in SveDem (N = 28,609); median follow-up 741 days. Observed deaths were 5,368 (19%). Measurements Information on number of deaths and causes of mortality was obtained from death certificates. Odds ratios for the presence of dementia on death certificates were calculated. Hazard ratios ( HRs) and 95% confidence intervals ( CIs) were calculated using Cox hazards regression for cause-specific mortality, using Alzheimer's dementia ( AD) as reference. Hazard ratios for death for each specific cause of death were compared with hazard ratios of death from all causes ( P-values from t-tests). Results The most frequent underlying cause of death in this cohort was cardiovascular (37%), followed by dementia (30%). Dementia and cardiovascular causes appeared as main or contributory causes on 63% of certificates, followed by respiratory (26%). Dementia was mentioned less in vascular dementia (VaD; 57%). Compared to AD, cardiovascular mortality was higher in individuals with VaD than in those with AD ( HR = 1.82, 95% CI = 1.64-2.02). Respiratory death was higher in individuals with Lewy body dementia ( LBD, including Parkinson's disease dementia and dementia with Lewy bodies, HR = 2.16, 95% CI = 1.71-2.71), and the risk of respiratory death was higher than expected from the risk for all-cause mortality. Participants with frontotemporal dementia were more likely to die from external causes of death than those with AD ( HR = 2.86, 95% CI = 1.53-5.32). Conclusion Dementia is underreported on death certificates as main and contributory causes. Individuals with LBD had a higher risk of respiratory death than those with AD. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AGE distribution
*ALZHEIMER'S disease
*CONFIDENCE intervals
*DEATH
*REPORTING of diseases
*LEWY body dementia
*LONGITUDINAL method
*RESEARCH methodology
*NOSOLOGY
*RESEARCH funding
*SEX distribution
*SURVIVAL analysis (Biometry)
*T-test (Statistics)
*COMORBIDITY
*LOGISTIC regression analysis
*DEATH certificates
*PROPORTIONAL hazards models
*DESCRIPTIVE statistics
*ODDS ratio
Subjects
Details
- Language :
- English
- ISSN :
- 00028614
- Volume :
- 64
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of the American Geriatrics Society
- Publication Type :
- Academic Journal
- Accession number :
- 119477478
- Full Text :
- https://doi.org/10.1111/jgs.14421