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Sofosbuvir plus simeprevir for the treatment of HCV genotype 4 patients with advanced fibrosis or compensated cirrhosis is highly efficacious in real life.
Sofosbuvir plus simeprevir for the treatment of HCV genotype 4 patients with advanced fibrosis or compensated cirrhosis is highly efficacious in real life.
- Source :
-
Journal of Viral Hepatitis . Dec2016, Vol. 23 Issue 12, p950-954. 5p. - Publication Year :
- 2016
-
Abstract
- Chronic hepatitis C virus ( HCV) infection is a major cause of chronic liver disease and liver-related death. Recently, multiple regimens of different direct-acting antiviral agents ( DAAs) have been registered. Although treatment with sofosbuvir ( SOF) and simeprevir ( SMV) is registered for the treatment of genotype 4 patients in some countries, data on efficacy of this combination are lacking. We aimed to assess the efficacy of SOF and SMV with or without RBV during 12 weeks in a real-life cohort of genotype 4 HCV patients. A retrospective multicentre observational study was conducted in 4 hospitals in Amsterdam, the Netherlands, including patients with advanced liver fibrosis or liver cirrhosis treated with SOF plus SMV with or without RBV during 12 weeks for a genotype 4 chronic HCV infection from 1 January 2015 to 1 August 2015. Sustained viral response ( SVR) was established at week 12 after end of treatment. A total of 53 patients with genotype 4 HCV infection, treatment naïve and experienced, were included. SVR was achieved in 49 of 53 patients (92%). The four failures all had a virological relapse and did not receive ribavirin. Three were nonresponder to earlier interferon-based treatment, and one was treatment naive. In this real-life cohort of patients with HCV genotype 4 infection and advanced liver fibrosis/cirrhosis, we show that treatment with SOF and SMV is effective. The addition of RBV could be considered in treatment-experienced patients as recommended in guidelines. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13520504
- Volume :
- 23
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journal of Viral Hepatitis
- Publication Type :
- Academic Journal
- Accession number :
- 119499367
- Full Text :
- https://doi.org/10.1111/jvh.12567