Back to Search
Start Over
Low-level viraemia, measured as viraemia copy-years, as a prognostic factor for medium-long-term all-cause mortality: a MASTER cohort study.
- Source :
-
Journal of Antimicrobial Chemotherapy (JAC) . Dec2016, Vol. 71 Issue 12, p3519-3527. 9p. - Publication Year :
- 2016
-
Abstract
- <bold>Objectives: </bold>We investigated the association between persistent low-level viraemia, measured as viraemia copy-years (VCY), and all-cause mortality.<bold>Methods: </bold>We included 3271 HIV-infected patients who initiated their first combined ART (cART) during 1998-2012 enrolled in the multicentre Italian MASTER cohort. VCY was defined as the area under the curve of plasma viral load (pVL) and expressed in log10 copies · years/mL. VCY was evaluated from cART initiation until the end of follow-up [VCY-overall (VCY-o)], and stratified into before [VCY-early (VCY-e)] and after [VCY-late (VCY-l)] the eighth month from starting cART, and as the ratio of VCY-l to follow-up duration (VCY-l/FUD).<bold>Results: </bold>The risk of death increased of about 40% for higher than the median levels of VCY-o and VCY-e. Compared with subjects with permanently suppressed pVL after the eighth month from starting cART, mortality increased by 70% for those with VCY-l ≥3 log10 copies·years/mL, and by about 20-fold for those with VCY-l/FUD ≥2.3 log10 copies/mL. Patients who maintained low levels of VCY-l (<3 log10 copies · years/mL) or VCY-l/FUD (<2.3 log10 copies/mL) had a risk of death similar to patients with permanently suppressed pVL. CD4 cell count at baseline was predictive of high risk of death only in subjects with VCY-l ≥3 log10 copies · years/mL.<bold>Conclusions: </bold>The risk of death did not increase in HIV-infected patients with low levels of VCY-l compared with patients with permanent virological suppression. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VIREMIA
*NEPHROTOXICOLOGY
*ETIOLOGY of diseases
*COHORT analysis
*DIAGNOSIS
*DISEASE risk factors
*ANTIRETROVIRAL agents
*COMPARATIVE studies
*HIV infections
*LONGITUDINAL method
*RESEARCH methodology
*MEDICAL cooperation
*PROGNOSIS
*RESEARCH
*RISK assessment
*SURVIVAL analysis (Biometry)
*TIME
*VIRAL load
*EVALUATION research
MORTALITY risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 03057453
- Volume :
- 71
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journal of Antimicrobial Chemotherapy (JAC)
- Publication Type :
- Academic Journal
- Accession number :
- 119550863
- Full Text :
- https://doi.org/10.1093/jac/dkw307