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Is elective single-embryo transfer a viable treatment policy in in vitro maturation cycles?
- Source :
-
Fertility & Sterility . Dec2016, Vol. 106 Issue 7, p1691-1695. 5p. - Publication Year :
- 2016
-
Abstract
- <bold>Objective: </bold>To compare the clinical outcome of single-embryo transfer (SET) with double-embryo transfer (DET) in in vitro maturation (IVM) cycles performed in patients with polycystic ovary syndrome (PCOS), and to determine which factors predict those outcomes.<bold>Design: </bold>A retrospective analysis.<bold>Setting: </bold>Private assisted reproduction center.<bold>Patient(s): </bold>One hundred and fifty-nine women with PCOS.<bold>Intervention(s): </bold>In vitro maturation with elective SET or DET conducted between September 2007 and May 2014.<bold>Main Outcome Measure(s): </bold>Live-birth rates.<bold>Result(s): </bold>Single-embryo transfer was performed in 83 patients (52.2%), and DET was performed in 76 patients (47.7%). When compared with the patients who had DET, the patients who had SET were statistically significantly younger (32.4 ± 3.5 vs. 24.1 ± 4.2 years) and had a shorter infertility duration (9.2 ± 4.5 vs. 4.4 ± 2.1 years), fewer previous ART cycles (<2 prior attempts, 39.5% vs. 6%; ≥2 prior attempts, 60.5% vs. 0), fewer collected oocytes (15.1 ± 4.6 vs. 12.6 ± 3.8), fewer metaphase II oocytes (9.0 ± 4.1 vs. 5.7 ± 2.9), fewer fertilized oocytes (8.2 ± 3.7 vs. 3.6 ± 2.3), and a higher implantation rate (27% vs. 47%). The SET and DET groups had similar embryo quality and similar clinical pregnancy (44.6% vs. 44.7%) and live-birth rates (34.9% vs. 34.2%). Twin pregnancy rates were statistically significantly higher in the DET compared with the SET groups (9.2% vs. 2.4%).<bold>Conclusion(s): </bold>In vitro maturation is a successful assisted reproduction technique that can be an alternative to conventional in vitro fertilization in women presenting with PCOS-related infertility. Our observations suggest that SET is a feasible option to prevent multiple pregnancies while maintaining the live-birth rate. [ABSTRACT FROM AUTHOR]
- Subjects :
- *POLYCYSTIC ovary syndrome
*EMBRYO transfer
*ELECTIVE surgery
*FERTILIZATION in vitro
*BIRTH rate
*HEALTH policy
*INFERTILITY treatment
*FERTILITY drugs
*COMPARATIVE studies
*FERTILITY
*HUMAN reproductive technology
*INFERTILITY
*RESEARCH methodology
*EVALUATION of medical care
*MEDICAL cooperation
*PREGNANCY
*RESEARCH
*PILOT projects
*EVALUATION research
*TREATMENT effectiveness
*RETROSPECTIVE studies
*DISEASE complications
*DIAGNOSIS
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 00150282
- Volume :
- 106
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Fertility & Sterility
- Publication Type :
- Academic Journal
- Accession number :
- 119559517
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2016.08.026