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Chalcone–benzoxaborole hybrids as novel anticancer agents.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Dec2016, Vol. 26 Issue 23, p5797-5801. 5p. - Publication Year :
- 2016
-
Abstract
- In this study, we report the synthesis of a series of chalcone–benzoxaborole hybrid molecules and the evaluation of their anticancer activity. Their anticancer potency and toxicity were tested on three human cancer cell lines and two normal cell lines. The 4-fluoro compound 15 was found to be the most potent compound with an IC 50 value of 1.4 μM on SKOV3 cells. The 4-iodo compound 18 and 3-methyloxy-4-amino compound 47 showed good potency on SKOV3 cells while exhibiting low toxicity on normal cells. This work extended the application of benzoxaboroles to the field of anticancer research. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHALCONE
*ANTINEOPLASTIC agents
*ORGANIC synthesis
*CANCER cells
*AMINO compounds
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 26
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 119583462
- Full Text :
- https://doi.org/10.1016/j.bmcl.2016.10.024