Back to Search
Start Over
Protective effect of the SOD/catalase mimetic MnTMPyP on inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuronal-glial cultures
- Source :
-
Journal of Neuroimmunology . Feb2004, Vol. 147 Issue 1/2, p68. 5p. - Publication Year :
- 2004
-
Abstract
- Reactive oxygen species (ROS) produced by activated microglia are deleterious to neurons. In this study, we studied the effect of Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin (MnTMPyP), a superoxide dismutase/catalase mimetic, on the lipopolysaccharide (LPS)-induced degeneration of dopaminergic neurons in rat mesencephalic neuroglia cultures. MnTMPyP exhibited a significantly protective effect against LPS (5 ng/ml)-induced neurotoxicity as determined by [3H]dopamine uptake and immunocytochemical analysis. MnTMPyP significantly attenuated LPS-induced production of superoxide free radical and prostaglandin E2 (PGE2) in microglia. These results indicate that MnTMPyP may potentially be used for the treatment of inflammation-related degenerative neurological disorders. [Copyright &y& Elsevier]
- Subjects :
- *REACTIVE oxygen species
*PROSTAGLANDINS
*NEURONS
*ENDOTOXINS
Subjects
Details
- Language :
- English
- ISSN :
- 01655728
- Volume :
- 147
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 11959270
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2003.10.040