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HBV Infection Status and the Risk of Cholangiocarcinoma in Asia: A Meta-Analysis.
- Source :
-
BioMed Research International . 11/23/2016, Vol. 2016, p1-14. 14p. - Publication Year :
- 2016
-
Abstract
- Background. The inconsistent finding was between hepatitis B virus (HBV) infections and cholangiocarcinoma (CCA). This meta-analysis is to explore this relationship in Asia. Methods. A literature search was performed using PubMed, Web of Science, and Cochrane Library to October 30, 2015. Pooled incidence rate and OR with 95% CI were calculated using STATA 11.0. Results. Thirty-nine studies were included. The pooled incidence rate of CCA patients with HBV infection was 31% (95% CI 22%–39%). The pooled OR showed increased risk of CCA incidence with HBV infection (OR = 2.72, 95% CI 1.90–3.88), especially in ICC (OR = 3.184, 95% CI 2.356–4.302), while it showed no risk in ECC (OR = 1.407, 95% CI 0.925–2.141). Also, the pooled OR showed increased risk of ICC and ECC incidence (OR = 6.857, 95% CI 4.421–10.633 and OR = 1.740, 95% CI 1.260–2.404) in patients with HBsAg+/HBcAb+. The pooled OR showed increased risk of ICC incidence (OR = 1.410, 95% CI 1.095–1.816) in patients with HBsAg−/HBcAb+. Conclusion. It is suggested that HBV infection is associated with an increased risk of CCA in Asia. Two HBV infection models (HBsAg+/HBcAb+ and HBsAg−/HBcAb+) increase the risk of CCA, and patients with HBsAg−/HBcAb+ also had a risk of ICC. This trial is registered with PROSPERO <ext-link>CRD42015029264</ext-link>. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHI-squared test
*CONFIDENCE intervals
*HEPATITIS B
*MEDICAL databases
*INFORMATION storage & retrieval systems
*MEDLINE
*META-analysis
*ONLINE information services
*PROBABILITY theory
*RESEARCH funding
*SYSTEMATIC reviews
*CHOLANGIOCARCINOMA
*DISEASE incidence
*DATA analysis software
*DESCRIPTIVE statistics
*ODDS ratio
*DISEASE complications
*DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Volume :
- 2016
- Database :
- Academic Search Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 119732052
- Full Text :
- https://doi.org/10.1155/2016/3417976