An aerobic oxidative aza-[4+2] cycloaddition induced by radical cation salt: Synthesis of dihydroquinazoline derivatives.

Authors :: Luo, Liangliang
Zhao, Xiaolong
Zhang, Liang
Yuan, Yu
Lü, Shiwei
Jia, Xiaodong
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Dec2016, Vol. 57 Issue 51, p5830-5833. 4p.
Publication Year :: 2016
Abstract: A facile and efficient radical cation salt-induced approach to dihydroquinazoline derivatives has been developed by sp 3 C H oxidation, and the method uses readily available glycine esters as the starting material under aerobic oxidation conditions without addition of any additive. The present method provides a convenient and practical route for construction of quinazoline skeleton. [ABSTRACT FROM AUTHOR]

Subjects :: *RING formation (Chemistry)
*RADICAL cations
*SALT
*QUINAZOLINE
*AROMATIC compound synthesis
*CHEMICAL derivatives

Language :: English
ISSN :: 00404039
Volume :: 57
Issue :: 51
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 119773484
Full Text :: https://doi.org/10.1016/j.tetlet.2016.11.052

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