Back to Search
Start Over
Global profiling of cellular targets of gambogic acid by quantitative chemical proteomics.
- Source :
-
Chemical Communications . 12/18/2016, Vol. 52 Issue 97, p14035-14038. 4p. - Publication Year :
- 2016
-
Abstract
- Gambogic acid has shown significant potential as an anti-cancer and anti-inflammatory compound; however, the molecular mechanism underlying the actions of gambogic acid, particularly its cellular target profiles, has not been investigated. In this study, we report the proteome-wide profiling of potential cellular targets of gambogic acid using quantitative mass spectrometry-based chemical proteomics. The target profiles of gambogic acid in living HeLa and K562 cells were identified, which strengthened our understanding of the mode of actions of the phytochemical. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PROTEOMICS
*ANTINEOPLASTIC agents
*PHYTOCHEMICALS
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 52
- Issue :
- 97
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 119811296
- Full Text :
- https://doi.org/10.1039/c6cc07581a