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Trigeminal star-like platinum complexes induce cancer cell senescence through quadruplex-mediated telomere dysfunction.
- Source :
-
Chemical Communications . 12/21/2016, Vol. 52 Issue 98, p14101-14104. 4p. - Publication Year :
- 2016
-
Abstract
- Two trigeminal star-like platinum complexes were synthesized to induce the formation of human telomere G-quadruplex (hTel G4) with extremely high selectivity and affinity. The induced hTel G4 activates strong telomeric DNA damage response (TDDR), resulting in telomere dysfunction and cell senescence. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PLATINUM compound synthesis
*CANCER cells
*DNA damage
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 52
- Issue :
- 98
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 119885652
- Full Text :
- https://doi.org/10.1039/c6cc08254h