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Resolving the Interface of Calcium Phosphate Formation on the Porous Bioceramics In Vitro.
- Source :
-
Journal of the American Ceramic Society . Dec2016, Vol. 99 Issue 12, p4107-4112. 6p. 5 Diagrams, 1 Graph. - Publication Year :
- 2016
-
Abstract
- Porous bioceramics have been widely studied for bone tissue engineering. A deep understanding on the mechanism of bone growth and biomineralization depends on the extracted interface information between the new precipitated calcium phosphates (CaPs) and the porous substrate at a nanometer scale. However, due to their intrinsic brittleness and the complexity of the sample shape, there is still lack of such information. Here, by a combination of focused ion beam ( FIB) and transmission electron microscopy ( TEM), in-situ cross-sectional electron transparent interface was prepared. The precipitated dense apatite layer is composed of individual microgranules which further consist of tiny flake-like crystals. The new crystallites grow along c-axis and are mostly oriented perpendicular to HA substrate. This preferred orientation is more pronounced in the presence of protein. This work offers a novel and feasible approach using FIB- TEM to in situ image porous bioceramic scaffold and precipitated apatite layer interface and can be extended to study many other biointerfaces. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00027820
- Volume :
- 99
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journal of the American Ceramic Society
- Publication Type :
- Academic Journal
- Accession number :
- 119951753
- Full Text :
- https://doi.org/10.1111/jace.14449