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Synthesis and biological activity of arylsulfonamide derivatives containing 2-arylamino- 4(3H)-quinazolinone.
- Source :
-
Journal of Pesticide Science . 2016, Vol. 41 Issue 4, p171-174. 4p. 2 Black and White Photographs, 2 Charts. - Publication Year :
- 2016
-
Abstract
- Twenty arylsulfonamide derivatives containing 2-arylamino-4(3H)-quinazolinone were synthesized and evaluated for their bioactivities. 4-Fluoro- N-(2-(4-oxo-2-(4-(trifluoromethoxy)phenyl)amino)quinazolin-3(4H)-yl)ethyl benzenesulfonamide, showed excellent activity both against Ralstonia solanacearum and Gibberella zeae with the inhibition rates of 100% (200 mg/L) and 95% (100 mg/L), and 69% (50 mg/L), respectively, exceeding that of the assigned commercial bactericide (thiodiazole-copper) and fungicide (hymexazol). The preliminary structure activity relationships (SAR) showed that both benzene rings of arylamino and arylsulfonamido moieties containing electron-withdrawing substitutes may be preferable for improving the bioactivity of target compounds. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1348589X
- Volume :
- 41
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Pesticide Science
- Publication Type :
- Academic Journal
- Accession number :
- 119996076
- Full Text :
- https://doi.org/10.1584/jpestics.D16-053