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Reduced Plasma miR-146a Is a Predictor of Poor Coronary Collateral Circulation in Patients with Coronary Artery Disease.
- Source :
-
BioMed Research International . 12/5/2016, Vol. 2016, p1-6. 6p. - Publication Year :
- 2016
-
Abstract
- Coronary collateral circulation (CCC), an alternative blood supply for ischemic myocardium, improves survival rates among patients with coronary artery disease (CAD). However, there remains a lack of biomarkers to discriminate between patients with poor or good CCC. In this study, we aimed to observe the relationship between plasma microRNA-146a (miR-146a) levels and the coronary collateral circulation (CCC). Additionally, we aimed to explore whether the plasma miR-146a level could serve as a blood-based biomarker for CCC in patients with CAD. We measured the plasma levels of vascular endothelial growth factor A (VEGF-A) and miR-146a in patients with CCC by ELISA and real-time PCR, respectively, according to the Rentrop grades. The results showed that the plasma miR-146a level is significantly increased in CAD patients with good CCC and significantly decreased in those with poor CCC. In contrast, although VEGFA expression in patients followed a similar trend as the CCC, the differences between the groups were not statistically significant. There was a positive correlation between plasma miR-146a levels and the Rentrop grading. In addition, receiver operator characteristic analysis showed that miR-146a could be a potent biomarker for identifying patients with poor CCC. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CORONARY circulation
*RNA physiology
*ANALYSIS of variance
*COLLATERAL circulation
*CORONARY disease
*CREATININE
*DIABETES
*ENZYME-linked immunosorbent assay
*GENE expression
*CARDIAC patients
*HYPERTENSION
*ISCHEMIA
*LOW density lipoproteins
*MYOCARDIUM
*POLYMERASE chain reaction
*RESEARCH funding
*RNA
*SMOKING
*STATISTICS
*TRIGLYCERIDES
*DATA analysis
*VASCULAR endothelial growth factors
*BODY mass index
*CONTROL groups
*RECEIVER operating characteristic curves
*DATA analysis software
*DESCRIPTIVE statistics
*BLOOD urea nitrogen
*CORONARY angiography
*PHYSIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Volume :
- 2016
- Database :
- Academic Search Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 119997599
- Full Text :
- https://doi.org/10.1155/2016/4285942