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High-resolution HLA A∼B∼DRB1 haplotype frequencies from the Ezer Mizion Bone Marrow Donor Registry in Israel.
- Source :
-
Human Immunology . Dec2016, Vol. 77 Issue 12, p1114-1119. 6p. - Publication Year :
- 2016
-
Abstract
- We have investigated HLA population alleles and haplotype frequencies for the ethnicities that comprise the contemporary population of Israel, using a large data set from the Ezer Mizion Bone Barrow Donor Registry. We genotyped 275,699 individuals at the HLA-A, -B and -DRB1 loci using HLA genotyping methods. HLA A∼B∼DRB1 haplotype frequencies were estimated from 19 sub-ethnic Jewish populations and other non-Jewish minorities using the maximum likelihood model, which accommodates typing ambiguities. We present overall and sub-ethnicity specific HLA diversity results of the registry, which will help guide a data-driven strategy for future registry expansion. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HLA histocompatibility antigens
*HAPLOTYPES
*ORGAN donors
*AMBIGUITY
Subjects
Details
- Language :
- English
- ISSN :
- 01988859
- Volume :
- 77
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Human Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 119999405
- Full Text :
- https://doi.org/10.1016/j.humimm.2016.09.004