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Increased frequency of the PTPN22W* variant in primary Sjogren's Syndrome: Association with low type I IFN scores.
- Source :
-
Clinical Immunology . Dec2016, Vol. 173, p157-160. 4p. - Publication Year :
- 2016
-
Abstract
- Recent data suggest the association of the autoimmune gene variant PTPN22W* with dampened type I Interferon (IFN) responses, seen in a subset of primary Sjogren's Syndrome (pSS) patients. We sought to explore the potential contribution of PTPN22W* in this setting. PTPN22W* was identified in DNA samples derived from 352 pSS patients and 482 healthy controls (HC). Type I IFN score was determined in available peripheral blood cDNA of 164 pSS patients by Real-Time PCR. Increased prevalence of the PTPN22W* variant was detected in pSS patients compared to HC [9.7% vs 5.0%, p-value: 0.02]. Of interest, only the low but not the high type I IFN pSS subgroup displayed higher PTPN22W* rates compared to HC (12.2% vs 5.0%, p-value: 0.03). PTPN22W* risk variant increases susceptibility for pSS, particularly the low type I IFN subset implying the presence of distinct genetic backgrounds among low and high type I IFN autoimmune subgroups. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15216616
- Volume :
- 173
- Database :
- Academic Search Index
- Journal :
- Clinical Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 119999686
- Full Text :
- https://doi.org/10.1016/j.clim.2016.10.015