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Inhalable clarithromycin liposomal dry powders using ultrasonic spray freeze drying.
- Source :
-
Powder Technology . Jan2017, Vol. 305, p63-70. 8p. - Publication Year :
- 2017
-
Abstract
- Liposomal dry powder inhalation for the pulmonary administration has a great potential to improve the efficacy of antibiotics while reducing adverse effects. To improve aerosolisation efficiency of liposomal dry powders, we prepared clarithromycin liposomal powder formulations (CLA-Lips-DPIs) by an ultrasonic spray freeze drying (USFD) method using 15% mannitol and 5% sucrose (W:V) as combination lyoprotectants (co-lyoprotectants). The formulation had a porous structure, comprising micron-sized particles with uniform drug content and high drug recovery. Co-lyoprotectants could modulate the liposomal powder from absorbing moisture, resulting in moisture absorption being < 15% (W/W) when stored at 75% relative humility for 2 h. The interaction of CLA, lyoprotectant and lipids of CLA-Lips-DPIs was investigated by differential scanning calorimetry. The reconstituted liposome suspension showed a high entrapment efficiency of up to 80% and a narrow size distribution due to the co-lyoprotectants protection. CLA-Lips-DPIs formulations remained unchanged after 3-month storage at 60% RH and 25 °C with a high aerosol efficiency (emitted dose > 85%, fine particle fraction 43%–50%). These results demonstrated the aerosolisation efficiency and storage of the CLA-Lips-DPIs formulation. Liposomal powder formulations prepared by USFD can potentially be an effective drug delivery system for delivering antibiotics. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00325910
- Volume :
- 305
- Database :
- Academic Search Index
- Journal :
- Powder Technology
- Publication Type :
- Academic Journal
- Accession number :
- 120142881
- Full Text :
- https://doi.org/10.1016/j.powtec.2016.09.053