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Dual pH/redox responsive and CD44 receptor targeting hybrid nano-chrysalis based on new oligosaccharides of hyaluronan conjugates.
- Source :
-
Carbohydrate Polymers . Feb2017, Vol. 157, p1272-1280. 9p. - Publication Year :
- 2017
-
Abstract
- A smart hybrid microenvironment-mediated dual pH/redox-responsive polymeric nanoparticles combined with inorganic calcium phosphate (CaP) was fabricated, which we term as armored nano-chrysalis inspired by butterfly pupa. The nano-chrysalis has an inner core composed of specially designed oligosaccharides of hyaluronan (oHA) targeting CD44 receptor. The inner core has two functions, i.e., the dual pH/redox responsive polymeric conjugate and the fluorescent curcumin-prodrug function. The prepared nano-chrysalis possessed a smaller size (102.5 ± 4.6 nm) than the unarmored nano-chrysalis (122.5 ± 6.6 nm). Interestingly, while the nano-chrysalis were stable under pH 7.4, when incubated under the tumor acidic conditions (pH 6.5) the outer CaP armor would dissolve in a pH-dependent, sustained manner. Moreover, nano-chrysalis was demonstrated to present the most effective antitumor efficacy than other formulations. This study provides a promising smart nano-carrier platform to enhance the stability, decrease the side effects, and improve the therapeutic efficacy of anticancer drugs. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PUPAE
*HYALURONIC acid
*OLIGOSACCHARIDES
*CD44 antigen
*TUMORS
Subjects
Details
- Language :
- English
- ISSN :
- 01448617
- Volume :
- 157
- Database :
- Academic Search Index
- Journal :
- Carbohydrate Polymers
- Publication Type :
- Academic Journal
- Accession number :
- 120226656
- Full Text :
- https://doi.org/10.1016/j.carbpol.2016.10.089