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Folic acid-modified soy protein nanoparticles for enhanced targeting and inhibitory.
- Source :
-
Materials Science & Engineering: C . Feb2017, Vol. 71, p298-307. 10p. - Publication Year :
- 2017
-
Abstract
- Soy protein isolate (SPI) was hydrolyzed by compound enzymes to give water soluble low molecular soy protein (SP). SP and folic acid (FA) modified SP was polymerized with N-3- acrylamidophenylboronic acid (APBA) monomer in aqueous solution to give SP nanoparticles (SP NPs) and FA modified nanoparticles (FA-SP NPs), respectively. These NPs display excellent stability in different conditions, and have a uniform spherical shape with a diameter around of 200 nm. Doxorubicin (DOX) was then successfully loaded into SP and FA-SP NPs with a desirable loading content of 13.33% and 16.01%, respectively. The cellular uptake and cytotoxicity of DOX-loaded SP NPs and FA-SP NPs were investigated using the two-dimensional (2D) monolayer cell model and three-dimensional (3D) multicellular spheroids (MCs). In vivo, tumor accumulation and growth inhibitory were then examined using H22 tumor-bearing mice. All these results demonstrated that conjugation of FA can efficiently enhance SP-based NPs' tumor accumulation and antitumor effect. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FOLIC acid
*SOY proteins
*NANOPARTICLES
*TARGETED drug delivery
*ENZYME inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 09284931
- Volume :
- 71
- Database :
- Academic Search Index
- Journal :
- Materials Science & Engineering: C
- Publication Type :
- Academic Journal
- Accession number :
- 120242141
- Full Text :
- https://doi.org/10.1016/j.msec.2016.10.018