Allergic contact dermatitis from benzydamine with probable cross-reaction to indomethacin.

Benzydamine is a non-steroidal anti-inflammatory drug from which contact dermatitis from topical application and photodermatitis from both topical and systemic administration have been described. A 58-year-old man developed eczema after the application of Tantum fuerte cream, containing 5% benzydamine hydrocloride without preceding sun exposure. Patch tests gave strong positive reaction to benzydamine hydrochloride and to an essential oil Aurea Crematest. This is the 1st case of allergic contact dermatitic from benzydamine in which a positive patch test to indomethacin has also been described.