Back to Search
Start Over
Palm dermatoglyphs and interleukin-4 receptor polymorphisms in asthma.
- Source :
-
Biomedical Reports . Jan2017, Vol. 6 Issue 1, p21-26. 6p. - Publication Year :
- 2017
-
Abstract
- Single nucleotide polymorphisms (SNPs) in the interleukin-4 receptor (IL-4R) gene have been identified as having a close association with asthma severity in different populations. In our previous studies, a close association between asthma and a distinctive palm dermatoglyphic pattern was observed; however, the clinical implication and underlying genetic mechanisms of this particular palm pattern have not been clarified. Whether this particular palm pattern is associated with asthma severity and IL-4R SNPs was assessed in the present study. A case cohort study was conducted in 400 patients with allergic asthma and in 200 healthy controls. DNA was extracted from peripheral blood leukocytes for analysis of 11 IL-4R SNPs associated with asthma via polymerase chain reaction. There are two SNPs, rs1805012 and rs3024608, which are associated with asthma (rs1805012, dominant model; P=0.03 and rs3024608, codominant model; P=0.029), and two SNPs, rs1805010 and rs3024608, which are associated with the positive palm pattern (rs1805010, log-additive model; P=0.031 and rs3024608, codominant model; P=0.016). The SNP of rs3024608 is associated with asthma and the positive palm pattern. Thus, genetic variation in IL-4R may be associated with the development of asthma and the distinctive palm pattern; however, further investigations are required to identify the connection between asthma and palm dermatoglyphic patterns. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20499434
- Volume :
- 6
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biomedical Reports
- Publication Type :
- Academic Journal
- Accession number :
- 120359760
- Full Text :
- https://doi.org/10.3892/br.2016.803