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Functionalization of NH-unsubstituted androstano[17,16- d]pyrazoles. Synthesis of 2-arylamino-2-thioxoacetylandrostano[17,16- d]pyrazoles.
- Source :
-
Russian Chemical Bulletin . Mar2016, Vol. 65 Issue 3, p819-821. 3p. - Publication Year :
- 2016
-
Abstract
- An approach to the synthesis of earlier unknown androstano[17,16-d]pyrazoles containing a monothiooxamide fragment at the nitrogen atom of the pyrazole ring has been suggested. The method is based on the reaction of NH-unsubstituted androstano[17,16-d]pyrazole with chloroacetyl chloride with subsequent involvement of the obtained N-chloroacetylpyrazole into the reaction with elementary sulfur in the presence of aromatic amines. The synthesized androstano[17,16-d]pyrazoles containing a monothiooxamide fragment at the nitrogen atom of the pyrazole ring exhibit high antiparasitic activity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10665285
- Volume :
- 65
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Russian Chemical Bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 120383762
- Full Text :
- https://doi.org/10.1007/s11172-016-1381-4