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Preparation of dimethyl (R)- and (S)-2-(2-aminophenyl)-2-hydroxyethylphosphonate from anthranilic acid
- Source :
-
Tetrahedron: Asymmetry . Feb2004, Vol. 15 Issue 3, p457. 7p. - Publication Year :
- 2004
-
Abstract
- An efficient synthesis of both enantiomers of dimethyl δ-amino-β-hydroxyethylphosphonate 6 has been achieved starting from anthranilic acid, through the resolution of dimethyl (±)-2-(2-N,N-dibenzylaminophenyl)-2-hydroxyethylphosphonate 9 with (S)-O-methylmandelic acid. The absolute configuration of the enantiomers 9 was assigned by the Dale and Mosher approach using the extended Newman projections and molecular mechanics. [Copyright &y& Elsevier]
- Subjects :
- *ENANTIOMERS
*PHOSPHONATES
*MOLECULES
*AMINO compounds
Subjects
Details
- Language :
- English
- ISSN :
- 09574166
- Volume :
- 15
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Tetrahedron: Asymmetry
- Publication Type :
- Academic Journal
- Accession number :
- 12040234
- Full Text :
- https://doi.org/10.1016/j.tetasy.2003.11.038