Olfactory response modeling of mouse muscone receptor MOR215-1 to binary muscone enantiomers odor by statistical physics models.

In this paper, an adsorption modeling has been presented to describe the interactions of a binary mixture of ℓ-muscone and d-muscone with the mouse muscone receptor MOR215-1. The formulation of the 2-dimensional monolayer models with identical and two types of sites for the perceived response of odor binary mixture odor are based on statistical physics and some theoretical hypothesis, in order to model pure and binary mixture dose-response curves. Thanks to the grand canonical ensemble of statistical physics, some pertinent physico-chemical parameters describing the adsorption process were introduced in the analytical model expressions. The results showed a high correlation of the 2-dimensional monolayer model using two types of sites with binary mixture of ℓ-muscone and d-muscone response curve. In this model, six physico-chemical parameters derived from the fitting of the experimental data by a numerical simulation were discussed. Furthermore, these statistical physics models include physico-chemical parameters specific to the respective effects of each compound in the binary mixture, which may help to clarify the inhibitory effects that are often seen in ℓ-muscone and d-muscone mixture through the determination of the involved new steric parameters. In addition, the calculation of the molar adsorption energies showed that the two muscone enantiomers and their racemic were physisorbed onto cell surface neurons. [ABSTRACT FROM AUTHOR]