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Study of the Alpha-l-Fucosidase Langmuir Monolayer at the Air-Water Interface.
- Source :
-
Journal of Physical Chemistry A . Dec2016, Vol. 120 Issue 50, p12843-12849. 7p. - Publication Year :
- 2016
-
Abstract
- Alpha-l-fucosidase is a known biomarker for hepatocellular carcinoma that has shown great potential in diagnostics. Most of the focus for this enzyme has been on the free form found in serum; however, little is known of the properties of the minor portion of membrane-bound alpha-l-fucosidase. To better understand the properties of membrane-bound alpha-l-fucosidase, this enzyme was surveyed at the air-water interface. Alpha-l-fucosidase is able to form a stable Langmuir monolayer, which was confirmed through surface-pressure and surface-potential area isotherms, as well as infrared reflection-absorption spectroscopy (IRRAS). Furthermore, an interaction between the alpha-l-fucosidase Langmuir monolayer and a specific antibody for this enzyme, FUCA2, was observed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FUCOSIDASES
*LANGMUIR probes
*AIR-water interfaces
*LIVER cancer
*SURFACE chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 10895639
- Volume :
- 120
- Issue :
- 50
- Database :
- Academic Search Index
- Journal :
- Journal of Physical Chemistry A
- Publication Type :
- Academic Journal
- Accession number :
- 120422006
- Full Text :
- https://doi.org/10.1021/acs.jpcb.6b09094