Back to Search
Start Over
Natural NO inhibitors from the leaves of Callicarpa kwangtungensis: Structures, activities, and interactions with iNOS.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Feb2017, Vol. 27 Issue 3, p670-674. 5p. - Publication Year :
- 2017
-
Abstract
- A phytochemical investigation to obtain new NO inhibitors resulted in the isolation of a new diterpenoid with a rare 9,10- seco -abietane skeleton ( 1 ) and twelve known terpenoids ( 2 – 13 ) from Callicarpa kwangtungensis . Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analyses, and the absolute configuration of compound 1 was established by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. The inhibitory activities on lipopolysaccharide-induced NO production in murine microglial BV-2 cells of these terpenoids were evaluated, and all of the compounds showed inhibitory effects. The following molecular docking studies showed interactions of the bioactive compounds with the iNOS protein. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 27
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 120755937
- Full Text :
- https://doi.org/10.1016/j.bmcl.2016.11.044