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Performance of a novel atrazine-induced cerebellar toxicity in quail (Coturnix C. coturnix): Activating PXR/CAR pathway responses and disrupting cytochrome P450 homeostasis.
- Source :
-
Chemosphere . Mar2017, Vol. 171, p259-264. 6p. - Publication Year :
- 2017
-
Abstract
- Atrazine is well known to be a biologically hazardous substance with toxic effects, but atrazine-induced neurotoxicity remains unclear. The aim of this study was to investigate the mechanisms of atrazine-induced cerebellar toxicity. To determine atrazine-exerted potential neurotoxicity, quails were treated with 50, 250 and 500 mg/kg atrazine by gavage administration for 45 days. Notably, the changes of cytochrome P450 enzyme system (CYP450s) were observed in atrazine-exposed quails. The contents of cytochrome P450 (CYP450) and Cytochrome b5 (Cyt b5) and the activities of NADPH-cytochrome c reductase (NCR), aminopyrin N-demethylase (APND) and aniline-4-hydeoxylase (AH) were increased and erythromycin N-demethylase (ERND) was decreased in quail cerebellum. Nuclear xenobiotic receptors (NXRs) and the transcriptions of NXRs-related target molecules were influenced in cerebellum. Atrazine disrupted the CYP450s balance in quail cerebellum. These results suggested that atrazine-induced cerebellar toxicity in birds was associated with activating PXR/CAR pathway responses and disrupting cytochrome P450 homeostasis. This study provided novel evidences that atrazine exposure induced cerebellar toxicity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ATRAZINE
*CYTOCHROME P-450
*HOMEOSTASIS
*NEUROTOXICOLOGY
*DRUG administration
Subjects
Details
- Language :
- English
- ISSN :
- 00456535
- Volume :
- 171
- Database :
- Academic Search Index
- Journal :
- Chemosphere
- Publication Type :
- Academic Journal
- Accession number :
- 120756725
- Full Text :
- https://doi.org/10.1016/j.chemosphere.2016.12.075