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Transcriptional regulation of cytochrome c oxidase subunits in rat brain following sodium arsenite exposure.
- Source :
-
Toxicological & Environmental Chemistry . Mar2017, Vol. 99 Issue 3, p505-515. 11p. - Publication Year :
- 2017
-
Abstract
- Oxidative stress-mediated mitochondrial dysfunction is considered the major mechanism of arsenic-induced neurotoxicity. With the present study, the regulation of the 13 subunits of cytochrome c oxidase in rat brain following arsenic exposure was evaluated. Rats were exposed to sodium arsenite (2.5 mg/kg b.wt., by gavage) for 12 weeks. The mRNA expression of the subunits was analysed using reverse transcription polymerase chain reaction. The mRNA expression of all the mitochondria-encoded subunits and selective nuclear-encoded subunits was downregulated. Analysis of mRNA expression of nuclear respiratory factor-1 and nuclear respiratory factor-2 also showed downregulation. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 02772248
- Volume :
- 99
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Toxicological & Environmental Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 120809388
- Full Text :
- https://doi.org/10.1080/02772248.2016.1217537