Effect of RTI drug efficacy on the HIV dynamics with cocirculating target cells.

In this paper, we propose and analyze an HIV dynamics model. The model can be seen as a generalization of many HIV dynamics models presented in the literature since it incorporates (i) two classes of target cells, CD4+ T cells and macrophages, (ii) two types of infected cells, short-lived infected cells and the long-lived chronically infected cells, (iii) intracellular discrete delays, (iv) reverse transcriptase inhibitors (RTIs) drugs with different drug efficacies on CD4+T cells and macrophages. The incidence rate of infection is represented by a general function. A bifurcation parameter, known as the basic reproduction number, R0 is derived. We established a set of conditions on the general function which are sufficient to determine the global dynamics of the model. Using Lyapunov functionals and LaSalle's invariance principle, the global asymptotic stability of the two equilibria of the model is obtained. An example is presented and some numerical simulations are conducted in order to illustrate the dynamical behavior. [ABSTRACT FROM AUTHOR]