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Initial energy supplementation in critically ill patients receiving enteral nutrition: a systematic review and meta-analysis of randomized controlled trials.
- Source :
-
Asia Pacific Journal of Clinical Nutrition . Mar2017, Vol. 26 Issue 1, p11-19. 9p. - Publication Year :
- 2017
-
Abstract
- <bold>Background and Objectives: </bold>Here we systematically reviewed and quantitatively analyzed randomized controlled trials (RCTs) to compare the important initial outcomes of critically ill adults receiving low- and highenergy enteral nutrition.<bold>Methods and Study Design: </bold>RCTs comparing low- and high-energy supplementation in critically ill adults receiving enteral nutrition admitted to the intensive care unit for an expected stay of >48 h were included. Abstracts submitted to major scientific meetings were included and the primary endpoint was mortality. The risk ratio (RR) and weighted mean difference (WMD) with 95% confidence intervals (CIs) were the effect measures.<bold>Results: </bold>Eleven RCTs (3,212 patients) were included. The groups did not differ significantly in mortality (RR, 0.94; 95% CI, 0.80-1.11; p=0.47), infections morbidity (RR 1.09; 95% CI 0.95-1.26; p=0.23), pneumonia morbidity (RR 1.04; 95% CI 0.88-1.23; p=0.68), hospital length of stay (WMD -0.27; 95% CI -3.21 to 3.76; p=0.88), intensive care unit length of stay (WMD -0.32; 95% CI, -1.81 to 1.16; p=0.46), mechanical ventilation days (WMD -0.30; 95% CI-1.42 to 0.82; p=0.60). The incidence of gastrointestinal intolerance was significantly lower in the low-energy group (RR 0.79; 95% CI 0.65-0.97; p<0.05).<bold>Conclusions: </bold>The initial administration of low- versus high-energy supplements did not impact clinical outcomes except for gastrointestinal intolerance in non-malnourished critically ill patients receiving enteral nutrition. The initial administration of highrather than low-energy may benefit these patients by reducing infections, but this effect might actually be attributable to the concomitant high protein intake. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09647058
- Volume :
- 26
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Asia Pacific Journal of Clinical Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 120964589
- Full Text :
- https://doi.org/10.6133/apjcn.102015.11