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Influence of polymer coating on release of l-dopa from core-shell Fe@Au nanoparticle systems.
- Source :
-
Colloid & Polymer Science . Feb2017, Vol. 295 Issue 2, p391-402. 12p. - Publication Year :
- 2017
-
Abstract
- We report on the effect of different stimuli-responsive polymer shells on Fe@Au core-shell nanoparticles (NPs) with respect to thermoresponse as well as loading and release characteristics. The hybrid NP systems were investigated using a wide array of characterization techniques including dynamic light scattering, electrophoretic mobility, UV-visible spectroscopy, and scanning transmission electron microscopy. Three different polymeric shells were selected for loading and release of l-dopa: thiolated polyethylene glycol (PEG), poly( N-isopropylacrylamide- co-acrylic acid) (PNIPAAM_AAc) microgel crosslinked with N, N′-methylenebis(acrylamide) (BIS), and finally concomitant PEG and PNIPAAM_AAc microgel (Fe@Au_PEG_Microgel). All three shells were found to exhibit high loading (∼10%) and encapsulation efficiencies up to 100 μg l-dopa/mg. Although the loading efficiencies are comparable for the three systems, Fe@Au_PEG_Microgel has the highest release (87%) at elevated temperature and acidic conditions. The attenuated release from the PEG-based systems can be attributed to stronger dipole-dipole interactions between the carboxyl group of PEG and the amino group of l-dopa. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DOPA
*NANOPARTICLES
*LIGHT scattering
*ULTRAVIOLET spectroscopy
*MICROGELS
Subjects
Details
- Language :
- English
- ISSN :
- 0303402X
- Volume :
- 295
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Colloid & Polymer Science
- Publication Type :
- Academic Journal
- Accession number :
- 121002096
- Full Text :
- https://doi.org/10.1007/s00396-017-4015-y