Silver complexes of ligands derived from adamantylamines: Water-soluble silver-donating compounds with antibacterial properties.

Two new silver(I) complexes, namely [Ag(qyAm) 2 ](CF 3 SO 3 ) ( 1 ) and [Ag(qyTAm) 2 ](CF 3 SO 3 ) ( 2 ), (qyAm = 2-(quinonyl)iminoadamantane, qyTAm = 2-(quinonyl)iminotriazaadamantane) have been synthesized and characterized by elemental analyses, 1 H NMR, IR, electronic absorption spectroscopy, and X-ray diffraction. The coordination geometry of the silver center in both complexes is distorted tetrahedral where their respective qyAm and qyTAm ligand bind in a bidentate fashion using the imine and quinoline nitrogen atoms. Complex 2 is soluble in water and exhibits strong antimicrobial actions on both Gram-negative ( E . coli , and P . aeruginosa ) and Gram-positive ( S . aureus ) bacteria. The minimal inhibitory concentration (MIC) values for complex 2 (4, 4, and 8 μg for E . coli , P . aeruginosa , and S . aureus , respectively) are comparable to MIC values of silver nitrate and silver sulfadiazine. [ABSTRACT FROM AUTHOR]