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Correlation between miR-148 Expression in Vitreous and Severity of Rhegmatogenous Retinal Detachment.
- Source :
-
BioMed Research International . 2/5/2017, Vol. 2017, p1-8. 8p. - Publication Year :
- 2017
-
Abstract
- Purpose. We had earlier reported positive hsa-miR-148a-3p expression in eyes with rhegmatogenous retinal detachment (RRD) and its involvement in the epithelial-mesenchymal transition of retinal pigment epithelium in vitro. Here we investigated the association of hsa-miR-148a-3p expression levels in the vitreous fluid of patients with RRD with severity of RRD. Methods. The hsa-miR-148a-3p expression levels in the vitreous fluid, range (degree) of retinal detachment (RD), and pixels of retinal break were measured in 27 eyes with RRD. The association of hsa-miR-148a-3p expression levels with other factors was evaluated by multiple regression analysis. Results. The hsa-miR-148a-3p expression levels, time from onset of RRD to vitrectomy, range of RD, and pixels of retinal breaks were 23.68±43.00, 12.07±15.36 days, 155.85±86.67 degrees, and 37000±67100 pixels, respectively. Five eyes with RRD had vitreous hemorrhage preoperatively. The hsa-miR-148a-3p expression levels were significantly associated with pixels of retinal breaks (β=0.699) and the time from onset of RRD to vitrectomy (β=0.358) but not with the range of RD or presence of vitreous hemorrhage. Conclusion. The hsa-miR-148a-3p expression levels in the vitreous fluid were significantly associated with the size of retinal break and disease duration. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RNA analysis
*OPHTHALMIC surgery
*HEMORRHAGE
*OPHTHALMOSCOPY
*POLYMERASE chain reaction
*PROBABILITY theory
*REGRESSION analysis
*RESEARCH funding
*RETINAL diseases
*RETINAL detachment
*RNA
*STATISTICS
*VITREOUS body
*DATA analysis
*MULTIPLE regression analysis
*SEVERITY of illness index
*DISEASE duration
*DESCRIPTIVE statistics
*MANN Whitney U Test
*DISEASE complications
*SURGERY
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Volume :
- 2017
- Database :
- Academic Search Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 121122340
- Full Text :
- https://doi.org/10.1155/2017/3427319