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Schisandra chinensis and Its Main Constituent Schizandrin Attenuate Allergic Reactions by Down-Regulating Caspase-1 in Ovalbumin-Sensitized Mice.
- Source :
-
American Journal of Chinese Medicine . 2017, Vol. 45 Issue 1, p159-172. 14p. 1 Diagram, 4 Graphs. - Publication Year :
- 2017
-
Abstract
- Schisandra chinensis (SC) and its main constituent, schizandrin (SCH) exhibit anti-inflammatory and anti-allergic activities. Allergic and inflammatory reactions are aggravated via caspase-1 signaling pathway. However, the regulatory effects of SC and SCH on caspase-1 activation have not been clarified yet. In this study, we aimed to clarify the anti-allergic effects of SC and SCH using an ovalbumin (OVA)-sensitized mice and anti-CD3 and anti-CD28 antibodies-stimulated splenocytes. SC or SCH significantly inhibited the levels of immunoglobulin (Ig)E, IgG1, or interleukin (IL)-4 in serum of OVA-sensitized mice. SC or SCH significantly inhibited the levels of IL-6, tumor necrosis factor (TNF)-, and IL-1 in spleen of the OVA-sensitized mice. SC or SCH significantly suppressed the expression of caspase-1 and receptor-interacting protein (RIP)-2 in spleen of the OVA-sensitized mice. In activated splenocytes, SC or SCH significantly decreased the expression of caspase-1 and RIP-2 as well as the production of IL-6 and TNF-. We suggest that SC and SCH exert an anti-allergic effect by down-regulating caspase-1 signaling. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALLERGY prevention
*INFLAMMATION prevention
*ANIMAL experimentation
*BIOLOGICAL models
*CELL culture
*CELLULAR signal transduction
*CYTOKINES
*GENE expression
*HIGH performance liquid chromatography
*IMMUNOGLOBULINS
*INTERLEUKINS
*LIGNANS
*MAST cells
*MEDICINAL plants
*MICE
*RESEARCH funding
*SPLEEN
*TUMOR necrosis factors
*WESTERN immunoblotting
*PLANT extracts
*DATA analysis software
*DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 0192415X
- Volume :
- 45
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- American Journal of Chinese Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 121124945
- Full Text :
- https://doi.org/10.1142/S0192415X17500112