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Biomimetic apatite formed on cobalt-chromium alloy: A polymer-free carrier for drug eluting stent.
- Source :
-
Colloids & Surfaces B: Biointerfaces . Mar2017, Vol. 151, p156-164. 9p. - Publication Year :
- 2017
-
Abstract
- In this study, sirolimus (SRL) was loaded within biomimetic apatite formed on cobalt-chromium (Co-Cr) alloy, which has been reported for the first time, to inhibit the in-stent restenosis. Two different groups of loading SRL within biomimetic apatite were prepared: Group A (mono-layer of apatite/SRL) and Group B (bi-layer of apatite/SRL). Group A and Group B showed the biphasic pattern of SRL release up to 40 and 90 days, respectively. The attachment of human artery smooth muscle cell (HASMC) for both Group A and Group B was significantly inhibited, and proliferation dramatically decreased with the release of SRL. Noteworthily, biomimetic apatite alone also suppressed the SMC proliferation. The porous biomimetic apatite uniformly covered Co-Cr stent without crack or webbings. After balloon expansion, the integrity of biomimetic apatite was sufficient to resist delamination or destruction. Thus, this study demonstrated that biomimetic apatite is a promising drug carrier for potential use in stents. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COBALT alloys
*BIOMIMETIC materials
*APATITE
*POLYMERS
*DRUG-eluting stents
Subjects
Details
- Language :
- English
- ISSN :
- 09277765
- Volume :
- 151
- Database :
- Academic Search Index
- Journal :
- Colloids & Surfaces B: Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 121131994
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2016.12.021