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Total Synthesis of (±)-Dihydroisosubamol.
- Source :
-
Advanced Synthesis & Catalysis . 3/6/2017, Vol. 359 Issue 5, p866-874. 9p. - Publication Year :
- 2017
-
Abstract
- We herein report the first total synthesis of the dibenzocycloheptanoide (±)-dihydroisosubamol. The key step includes a recently developed gold-catalysed hydroarylation reaction for the construction of the dibenzocycloheptene motif. Additional steps are a Suzuki-Miyaura cross coupling, a palladium-catalysed hydroxylation and an allylic oxidation. To access the saturated seven-membered ring system an iridium-catalysed hydrogenation proved to be successful. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ARYLATION
*PALLADIUM
*HYDROXYLATION
*CHEMICAL reactions
*OXIDATION
Subjects
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 359
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 121542625
- Full Text :
- https://doi.org/10.1002/adsc.201600663