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Impaired CD4 T-Cell Response to Autophagy in Treated HIV-1–Infected Individuals.
- Source :
-
JAIDS: Journal of Acquired Immune Deficiency Syndromes . Feb2017, Vol. 74 Issue 2, p201-205. 5p. 1 Chart, 1 Graph. - Publication Year :
- 2017
-
Abstract
- Autophagy restricts infection of CD4 T lymphocytes by HIV-1, but little is known about autophagy in treated HIV-1–infected individuals. We have analyzed the capability of CD4 T cells from aviremic-treated individuals to trigger autophagy and correlated this response with parameters known to be important for immunological recovery. Autophagy was significantly decreased in CD4 T cells from HIV-1–treated individuals compared with uninfected controls, and this defective autophagic response was more pronounced in individuals with poor CD4 T-cell recovery, suggesting a link between impaired autophagy in CD4 T cells and chronic immunological defects that remain in treated HIV infection. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15254135
- Volume :
- 74
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- JAIDS: Journal of Acquired Immune Deficiency Syndromes
- Publication Type :
- Academic Journal
- Accession number :
- 121555740
- Full Text :
- https://doi.org/10.1097/QAI.0000000000001201