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An efficient, scalable approach to hydrolyze flavonoid glucuronides via activation of glycoside bond.
- Source :
-
Tetrahedron . Apr2017, Vol. 73 Issue 14, p1895-1903. 9p. - Publication Year :
- 2017
-
Abstract
- Hydrolyzing flavonoid glucuronides into corresponding aglycones posed some significant challenges. To improve acid-catalyzed hydrolysis process of flavonoid glucuronide, structures of glucuronide, hydrolysis parameters and post-processing were optimized. The optimized condition was performed by hydrolysis flavonoid glycoside methyl ester in a mixed solvent consisting of 2 mol/L H 2 SO 4 /EtOH/H 2 O (1/8/1, v/v/v) at 95 °C for 7 h and resulted in up to 90% aglycone yields, minimal byproduct formations and milder hydrolysis conditions. Furthermore, the optimized method avoids tedious purification steps and is easily conducted on a relatively large-scale using economical and commercially available reagents. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 73
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 121636817
- Full Text :
- https://doi.org/10.1016/j.tet.2017.02.039