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Factors predicting life-threatening infections with respiratory syncytial virus in adult patients.
- Source :
-
Infectious Diseases . May2017, Vol. 49 Issue 5, p333-340. 8p. 3 Charts, 2 Graphs. - Publication Year :
- 2017
-
Abstract
- Background:Respiratory syncytial virus (RSV) is a significant cause of acute respiratory illness with a clinical spectrum ranging from self-limiting upper respiratory infection to severe lower respiratory infection in elderly persons as well as young children. However, there are limited data on risk factors for life-threatening infections that could guide the appropriate use of antiviral agents in adult patients with RSV. Methods:We conducted a retrospective cohort study from October 2013 to September 2015. Adult patients with RSV who visited the emergency department were enrolled. Primary outcome was life-threatening infection (admission to intensive care unit, need for ventilator care or in-hospital death). Results:A total of 227 patients were analysed. Thirty-four (15%) were classified as having life-threatening infections. By logistic regression, lower respiratory infection, chronic lung disease and bacterial co-infection were independent predictors of life-threatening infections. We developed a simple clinical scoring system using these variables (lower respiratory tract infection = score 4, chronic respiratory disease = score 3, bacterial co-infection = score 3 and fever ≥38 °C = score 2) to predict life-threatening infection. A score of >5 differentiated life-threatening RSV from non-life-threatening RSV with 82% sensitivity (95% CI, 66–93) and 72% specificity (95% CI, 65–78). Conclusions:The use of a clinical scoring system based on lower respiratory infection, chronic respiratory disease, bacterial co-infection and fever appears to be useful for outcome prediction and risk stratification in order to select patients who may need early antiviral therapy. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *CARDIOVASCULAR disease diagnosis
*HYPERTENSION
*ANTIVIRAL agents
*ACADEMIC medical centers
*BACTERIAL diseases
*CHI-squared test
*COUGH
*DIABETES
*DYSPNEA
*FEVER
*FISHER exact test
*HEART diseases
*HOSPITAL care
*HOSPITAL emergency services
*LUNG diseases
*OBSTRUCTIVE lung diseases
*MEDICAL protocols
*MEDICAL societies
*PEDIATRICS
*POLYMERASE chain reaction
*PROGNOSIS
*RESEARCH funding
*RESPIRATORY infections
*SMOKING
*SPUTUM
*LOGISTIC regression analysis
*ACQUISITION of data
*RETROSPECTIVE studies
*DATA analysis software
*MANN Whitney U Test
*RESPIRATORY syncytial virus infections
*MIXED infections
*DISEASE complications
*SYMPTOMS
*DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 23744235
- Volume :
- 49
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 121663779
- Full Text :
- https://doi.org/10.1080/23744235.2016.1260769