Back to Search
Start Over
Palladium-Catalyzed Pyrazole-Directed sp3 C−H Bond Arylation for the Synthesis of β-Phenethylamines.
- Source :
-
Angewandte Chemie International Edition . 3/20/2017, Vol. 56 Issue 13, p3630-3634. 5p. - Publication Year :
- 2017
-
Abstract
- We have developed a method for palladium-catalyzed, pyrazole-directed sp3 C−H bond arylation by aryl iodides. The reaction employs a Pd(OAc)2 catalyst at 5-10 mol % loading and silver(I) oxide as a halide-removal agent, and it proceeds in acetic acid or acetic acid/hexafluoroisopropanol solvent. Ozonolysis of the pyrazole moiety affords pharmaceutically important β-phenethylamines. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PYRAZOLES
*ARYLATION
*ARYL iodides
*HALIDES
*OZONOLYSIS
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 56
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 121849102
- Full Text :
- https://doi.org/10.1002/anie.201611407