Mortalidad en pacientes con fiebre por sepsis tratados con paracetamol versus medios físicos.

BACKGROUND: Sepsis mortality in intensive and intermediate care units is high. To speak of fever is to speak of a factor that has been considered independent of mortality, since there are studies in which they evaluate the rate of elevation above of 38.3°C directly related to a worse prognosis for the patient1, it is currently unknown what is the most efficient way of treating it, whether with the use of antipyretic drugs or with the use of physical means2, and if these treatment modalities impact on mortality, All this remains controversial. MATERIALS AND METHODS: Randomized controlled trial in which treatment with acetaminophen IV against physical therapy was compared in patients who developed sepsis fever at the high speciality naval hospital in the area of hospitalization and intermediate care unit, follow-up was 28 days and the primary outcome was mortality. RESULTS: It was found that both treatment modalities are effective for the control of fever (p = 0.04), however regarding the primary objective that was the analysis of mortality did not report significant statistical difference (p = 0.11) We found a slight trend toward higher mortality in the acetaminophen group, so we conclude that a larger population sample is needed to make recommendations regarding mortality, now in relation to effectiveness and cost-benefit we conclude is better Treatment with physical means. [ABSTRACT FROM AUTHOR]