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Norepinephrine transporter blocker atomoxetine increases salivary alpha amylase.
- Source :
-
Psychoneuroendocrinology . Apr2017, Vol. 78, p233-236. 4p. - Publication Year :
- 2017
-
Abstract
- It has been suggested that central norepinephrine (NE) activity may be inferred from increases in salivary alpha-amylase (SAA), but data in favor of this proposition are limited. We administered 40 mg of atomoxetine, a selective NE transporter blocker that increases central NE levels, to 24 healthy adult participants in a double-blind, placebo-controlled cross-over design. Atomoxetine administration significantly increased SAA secretion and concentrations at 75–180 min after treatment (more than doubling baseline levels). Consistent with evidence that elevation in central NE is a co-determinant of hypothalamic-pituitary-adrenal axis activity, salivary cortisol also approximately doubled at the same time points. Moreover, changes in salivary cortisol positively correlated with SAA (0.44 < rho < 0.56), bolstering the position that the origin of the changes in SAA reflect central NE. This work points toward the potential value of SAA as an inexpensive and non-invasive procedure to obtain information about activation of the central NE system. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03064530
- Volume :
- 78
- Database :
- Academic Search Index
- Journal :
- Psychoneuroendocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 121913533
- Full Text :
- https://doi.org/10.1016/j.psyneuen.2017.01.029