Back to Search
Start Over
Ga proteins: molecular pharmacology and therapeutic potential.
- Source :
-
Cellular & Molecular Life Sciences . Apr2017, Vol. 74 Issue 8, p1379-1390. 12p. - Publication Year :
- 2017
-
Abstract
- Seven transmembrane G protein-coupled receptors (GPCRs) have gained much interest in recent years as it is the largest class among cell surface receptors. G proteins lie in the heart of GPCRs signalling and therefore can be therapeutically targeted to overcome complexities in GPCR responses and signalling. G proteins are classified into four families (G, G, G and G); G is further subdivided into four classes. Among them G and G isoforms are most crucial and ubiquitously expressed; these isoforms are almost 88% similar at their amino acid sequence but may exhibit functional divergences. However, uncertainties often arise about G and G inhibitors, these G proteins might also have suitability to the invention of novel-specific inhibitors for each isoforms. YM-254890 and UBO-QIC are discovered as potent inhibitors of G functions and also investigated in thrombin protease-activated receptor (PAR)-1 inhibitors and platelet aggregation inhibition. The most likely G protein involved in PAR-1 stimulates responses is one of the G family isoforms. In this review, we highlight the molecular structures and pharmacological responses of G family which may reflect the biochemical and molecular role of G and G. The advanced understanding of G and G role in GPCR signalling may shed light on our understanding on cell biology, cellular physiology and pathophysiology and also lead to the development of novel therapeutic agents for a number of diseases. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1420682X
- Volume :
- 74
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Cellular & Molecular Life Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 121918801
- Full Text :
- https://doi.org/10.1007/s00018-016-2405-9