Metal-Organic Framework@Porous Organic Polymer Nanocomposite for Photodynamic Therapy.

The limitation for the biomedical application of porous organic polymers (POPs) is the big size and poor dispersibility in aqueous media. Herein, a nanoscale metal-organic framework (MOF)@POP composite, named UNM, has been synthesized by epitaxial growth of the photoactive porphyrin-POPs (H2P-POP) on the outer surface of amine containing UiO-66 (UiO-AM). After the growth of POPs, the crystallization, pore structure, and size distribution of UNM are retained well. The formed UNM possesses a small size of less than 200 nm and could be internalized by cancer cells. Such light-activated UNM exhibits efficient ability to generate ¹O2 under various experimental conditions, which can be further applied for PDT efficacy. The present work demonstrates the great potential of nanoscale porous polymers in biomedical fields and cancer treatment. [ABSTRACT FROM AUTHOR]