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An Asymmetric Organocatalysis Approach to the Prenylated Alkaloid Family.
- Source :
-
Organic Letters . Mar2017, Vol. 19 Issue 6, p1338-1341. 4p. - Publication Year :
- 2017
-
Abstract
- Michael addition of a proline-derived triketopiperazine (TKP) to β-substituted enones and acrylamides, mediated by a cinchona alkaloid catalyst, delivers products possessing a bicyclo[2.2.2]diazaoctane structure in high yield and enantiomeric ratio (er). Further modification of the amide products toward polycyclic scaffolds resembling members of the prenylated alkaloid family is also demonstrated. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 19
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 121982972
- Full Text :
- https://doi.org/10.1021/acs.orglett.7b00193