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A two-step discriminated method to identify thermophilic proteins.
- Source :
-
International Journal of Biomathematics . May2017, Vol. 10 Issue 4, p-1. 8p. - Publication Year :
- 2017
-
Abstract
- Improving thermostability of an enzyme can accelerate the relevant chemical reaction. Thus, the analysis and prediction of thermophilic proteins are conducive to protein engineering and enzyme design. In this study, a novel method based on two-step discrimination was proposed to distinguish between thermophilic and non-thermophilic proteins. The model was rigorously benchmarked on an objective dataset including 915 thermophilic proteins and 793 non-thermophilic proteins. Results showed that the overall accuracy of our method is 94.44% in 5-fold cross-validation, which is higher than those of other published methods. We believe that the two-step discriminated strategy will become a promising method in the relevant field of protein bioinformatics. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PROTEIN analysis
*ENZYMES
*PROTEIN engineering
*BIOINFORMATICS
*CHEMICAL reactions
Subjects
Details
- Language :
- English
- ISSN :
- 17935245
- Volume :
- 10
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- International Journal of Biomathematics
- Publication Type :
- Academic Journal
- Accession number :
- 122080153
- Full Text :
- https://doi.org/10.1142/S1793524517500504