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Efficient synthesis of novel furo[2,3-d]pyrimidine derivatives under catalyst-free conditions.
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Apr2017, Vol. 58 Issue 16, p1572-1575. 4p. - Publication Year :
- 2017
-
Abstract
- A series of furo[2,3- d ]pyrimidine derivatives were synthesized via the [3+2] cyclization of pyrimidine-4,6-diol and a variety of nitroolefins at catalyst-free conditions. The reaction is easy to perform simply mixing inexpensive starting materials in water under conventional heating at 90 °C. The reaction proceeds at a fast speed within 1.5–2 h and gives the high biological and pharmacological active substituent furo[2,3- d ]pyrimidine derivatives with good to high yields. Mechanism of formation of these furo[2,3- d ]pyrimidine derivatives are also proposed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 58
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 122241090
- Full Text :
- https://doi.org/10.1016/j.tetlet.2017.03.019