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Direct access to 1,4-benzothiazine 4,4-dioxides and 4-oxides via a domino reaction.
- Source :
-
Tetrahedron . May2017, Vol. 73 Issue 18, p2656-2661. 6p. - Publication Year :
- 2017
-
Abstract
- The domino reactions of 2-fluoro benzensulfonyl acetonitrile and α-chloro oximes in the presence of Cs 2 CO 3 in aprotic high boiling point solvents have been achieved to provide isoxazole−fused 4 H -1,4-benzothiazine-4,4-dioxides via an unprecedented transition metal-free one-pot addition/cyclization process. The tunable synthesis of either isoxozolo-1,4-benzothiazin-4-oxides or their precursor 5-aminoisoxazoles can be controlled depending on the solvent selection. The observed products were characterized by means of (IR, 1 H, 13 C NMR and HRMS) and physical methods. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BENZOTHIAZINE
*ACETONITRILE
*SULFONYL compounds
*OXIMES
*BOILING-points
Subjects
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 73
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 122309789
- Full Text :
- https://doi.org/10.1016/j.tet.2017.03.056