Aristolochic acid derivatives from the rhizome of Arisolochia championii.

Four new aristolochic acid derivatives aristchamic A ( 1 ), aristchamic B ( 2 ), aristochamic C ( 3a ), aristchamic D ( 3b ) and one new aristolactam aristolactam-CV ( 4 ), together with 10 known compounds ( 5 – 14 ), were isolated from the rhizomes of Aristolochia championii . Their structures were assigned by detailed analysis of MS and NMR spectroscopic data. All of the isolated compounds were evaluated for their cytotoxic activities against HCT-116, HepG2, BGC-823, NCI-H1650, and A2780 cell. Compound 1 exhibited significant cytotoxic activity against HCT-116, HepG2, BGC-823, and NCI-H1650, with IC 50 values of 0.50, 7.37, 2.66, and 0.75 μM, respectively. [ABSTRACT FROM AUTHOR]