Overview of Current Treatment Strategies in Prostate Cancer

Prostate cancer is an escalating health problem. It comprises a wide spectrum of disease with varying biological potential and as a result, the optimal treatment at all the different stages of disease has been the subject of considerable debate. This paper gives an overview of the current thinking regarding optimal therapy at each stage plus and insight into ongoing studies of new treatment combinations. Hormone therapy is the mainstay of treatment in advanced, metastatic disease. The underlying mechanism in the development of hormone-resistant disease, and options to manage this condition, are currently being investigated. [Copyright &y& Elsevier]